Endocrine Abstracts

Introduction: Antithyroid drugs (ATD) are usually the first-line treatment for Graves’ disease (GD). It represents an effective treatment with good compliance. This therapeutic modality can be the cause of adverse effects including hematological, cutaneous and hepatic complications. The aim of our study is to evaluate the efficacy of ATD as well as its tolerance in patients with GD.Methods: It is a retrospective study that included 76 patients, with...

Introduction: Obesity in youth has become increasingly common. This study aims to determine the predictive factors of obesity in adolescents.Materials and Methods: This is an analytical cross-sectional study of a representative sample of high school students in the year 2019. Overweight and obesity were defined based on age- and sex-specific body mass index (BMI) z-score cutoffs. Data were analyzed using SPSS 20.0 software.Results:...

Introduction: Uncontrolled hyperglycemia in diabetes is a common cause of microvascular complications, including diabetic nephropathy (DN). Despite improvements in the management of type 2 diabetes (T2DM), diabetic nephropathy is still associated with high morbidity and mortality. The objective of our study is to evaluate the predictive factors of DN in adults with T2DM in order to prevent its development.Patients and Methods: A retrospective study, incl...

Introduction: Hirsutism is defined as excessive pilosity development in women in androgen-dependent areas. It is the main revealing sign of hyperandrogenism. It is a frequent reason for consultation in Endocrinology.Methods: This is a retrospective study of 82 records of patients hospitalized for exploration of hirsutism in the endocrinology department of Farhat Hached Hospital in Sousse, over a period of 20 years from 1997 to 2017.<p class="abstext"...

Introduction: Pseudopheochromocytoma is a poorly comprehended entity believed to arise from an overstimulated sympathetic nervous system. Individuals with pseudopheochromocytoma seem to demonstrate heightened cardiovascular reactivity to catecholamines, along with an increased release of epinephrine from the adrenal glands in response to stimulation from the sympathetic nervous system. This clinical report presents an observation of pseudopheochromocytoma in a patient diagnose...

Introduction: Gestational diabetes mellitus (GDM) arises from elevated glycemia during pregnancy, posing risks to both mother and fetus. Managing GDM involves close monitoring and dietary control, with antenatal insulin therapy (AIT). The aim of this study was to evaluate the efficiency of diverse maternal characteristics and biological indicators identified during GDM diagnosis in anticipating the inadequacy of dietary measures and the requirement for AIT to achieve glucose t...

Introduction : Few studies have considered the natural history of pituitary anatomy in Sheehan syndrome (SS), as seen on magnetic resonance imaging (MRI) or CT scan. An imaging study of the sella turcica was carried out in patients with SS. The aim was to look for correlations between radiological findings and the degree of endocrine insufficiency on the one hand, and diagnosis delay on the other.Methods: This is a retrospective study carried out between...

Introduction: Sheehan’s syndrome (SS) results from severe post-partum hemorrhage leading to necrosis of the pituitary gland. Here we describe the clinical characteristics of patients with Sheehan syndrome.Methods: We conducted a 44-year cohort study (1977 to 2021) of patients with SS followed at the endocrinology department of Farhat Hached Hospital in Sousse, Tunisia. Medical history, physical examination findings and laboratory investigations were...

Introduction: Hamartomas are benign tumors that occur in many different parts of the body. Brain locations of hamartoma are rare but still reported in few cases such as the tuber cinereum (TC) location. Children with hypothalamic hamartomas develop precocious puberty generally associated with gelastic seizures. However, TC hamartomas do not necessarily induce clinical symptoms. Amenorrhea has never been reported as a revealing symptom of TC hamartomas. Here we describe an atyp...

Introduction: Pituitary adenomas stand as the most prevalent form of tumorous pathology impacting the pituitary gland in adults. Their discovery might arise from either hypersecretion in functional adenomas or the manifestation of compression symptoms on neighboring structures. Detection of a pituitary adenoma can occur incidentally during various imaging modalities, encompassing both structural and functional assessments. This study documents a case involving the incidental d...